Heidelberg · Startup
The BioMed X Institute in Heidelberg, Germany, is establishing a new, fully funded research group in the field of:
Translocation of Complex Macromolecules Across the Intestinal Epithelial Barrier
If you hold a PhD or Master’s degree and have an outstanding track record or strong interest in the field of drug delivery, we invite you to apply with a project proposal for this position in our new research group (1 group leader, 2 postdoctoral researchers, 2 research assistants).
Each BioMed X project team is sponsored by an industry partner. The sponsor of this call for application is Janssen.
Complex macromolecules, including biologics such as monoclonal antibodies, have transformed the treatment of immune-related diseases, but they need to be delivered by injection, which limits their use relative to oral delivery. Although there are several techniques available to shield these macromolecules from the harsh conditions of the gastrointestinal tract, little progress has been made to translocate complex macromolecules across the intestinal epithelial barrier into systemic circulation.
The aim of this project is to discover novel transport mechanisms in the human intestinal tract which could be utilized for oral systemic delivery of diverse therapeutic modalities (e.g. peptides, oligonucleotides, and antibodies). The resulting delivery platform should enable the development of a new generation of oral immunotherapies for the benefit of patients. The key objectives include:
Proposals building on very original ideas supported by first experimental findings are particularly encouraged.
Group leader positions are intended to suit candidates who would like to develop themselves towards a leadership career path either in academia or industry and have typically between four and eight years of relevant postdoctoral research experience.
There is flexibility over starting dates, but successful applicants are welcome to take up post starting July 1, 2021.
BioMed X is an independent research institute located on the campus of the University of Heidelberg in Germany. Together with our partners, we identify big biomedical research challenges and provide creative solutions by combining global crowdsourcing with local incubation of the world’s brightest early-career research talents. Each of the highly diverse research teams at BioMed X has access to state-of-the-art research infrastructure and is continuously guided by experienced mentors from academia and industry. At BioMed X, we combine the best of two worlds – academia and industry – and enable breakthrough innovation by making biomedical research more efficient, more agile, and more fun. More info: https://bio.mx/